Inhibitoren der Nucleosidphosphorylierung in vivo / Inhibitors of Nucleoside Phosphorylation in vivo

Abstract

Acridinorange and pyronine inhibit the uptake and phosphorylation of nucleosides. The same doses of inhibitor do not yet interfere with RNA synthesis. An inhibition of similar specificity concerning nucleoside uptake is observed by several pyrimido-pyrimidine and pteridine derivatives. This inhibition can be reversed only by such nucleosides which are phosphorylated by the same nucleoside kinase. Several nucleoside analogues were also tested. We conclude that the inhibitors are interfering with the kinase reaction in vivo. The propagation of fowl plague virus (KP) is inhibited only by high doses of pyronine, yet neither by the pyrimido-pyrimidines nor the pteridines tested.