Correlation of fetal heart rate dynamics to inflammatory markers and brain-derived neurotrophic factor during pregnancy

Author:

Mercado Luis1,Rose Shannon2,Escalona-Vargas Diana12,Siegel Eric R.3,Whittington Julie R.1,Preissl Hubert4,Helmich Melissa1,Eswaran Hari1

Affiliation:

1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , University of Arkansas for Medical Sciences , Little Rock , AR , USA

2. Department of Pediatrics, Arkansas Children’s Research Institute , University of Arkansas for Medical Sciences , Little Rock , AR , USA

3. Department of Biostatistics , University of Arkansas for Medical Sciences , Little Rock , AR , USA

4. Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen , German Center for Diabetes Research (DZD) , Tübingen , Germany

Abstract

Abstract Objectives This study aims to show the relation between biomarkers in maternal and cord-blood samples and fetal heart rate variability (fHRV) metrics through a non-invasive fetal magnetocardiography (fMCG) technique. Methods Twenty-three women were enrolled for collection of maternal serum and fMCG tracings immediately prior to their scheduled cesarean delivery. The umbilical cord blood was collected for measurement of biomarker levels. The fMCG metrics were then correlated to the biomarker levels from the maternal serum and cord blood. Results Brain-derived neurotrophic factor (BDNF) had a moderate correlation with fetal parasympathetic activity (0.416) and fetal sympathovagal ratios (−0.309; −0.356). Interleukin (IL)-6 also had moderate-sized correlations but with an inverse relationship as compared to BDNF. These correlations were primarily in cord-blood samples and not in the maternal blood. Conclusions In this small sample-sized exploratory study, we observed a moderate correlation between fHRV and cord-blood BDNF and IL-6 immediately preceding scheduled cesarean delivery at term. These findings need to be validated in a larger population.

Funder

National Institute of Biomedical Imaging and Bioengineering

Sturgis Foundation for Diabetes Research, College of Medicine, Office of Research Intramural Grant Program

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

Walter de Gruyter GmbH

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