An analysis of factors affecting survival in prenatally diagnosed omphalocele

Author:

Ayhan Işıl1ORCID,Demirci Oya1ORCID,Uygur Lütfiye1ORCID,Odacilar Şahap1ORCID,Özbay Ayvaz Olga Devrim2ORCID,Karaman Ali3ORCID,Celayir Ayşenur2ORCID

Affiliation:

1. Department of Perinatology , University of Health Sciences, Zeynep Kamil Women and Children’s Diseases Training and Research Hospital , Istanbul , Türkiye

2. Department of Pediatric Surgery , University of Health Sciences, Zeynep Kamil Women and Children’s Diseases Training and Research Hospital , Istanbul , Türkiye

3. Department of Medical Genetics , University of Health Sciences, Zeynep Kamil Women and Children’s Diseases Training and Research Hospital , Istanbul , Türkiye

Abstract

Abstract Objectives To estimate factors affecting survival in prenatally diagnosed omphalocele, factors predicting genetic abnormalities, and association of omphalocele and specific groups of anomalies. Methods A retrospective observational study was performed, analyzing data of all omphalocele cases diagnosed prenatally in the perinatology clinic of a referral center. Demographic data, characteristics of the omphalocele (size, content, associated anomalies), results of genetic testing, pregnancy outcomes and postnatal outcomes were analyzed. Results Sixty-nine fetuses with omphalocele were included. The prevalence of omphalocele in livebirth was 0.007 %. Overall survival during the study period was 73.9 %. Twenty-eight (71.7 %) out of 39 cases with associated anomalies who were born live, survived, whereas survival was 85.7 % in the isolated cases. The most common anomaly associated with omphalocele were cardiac defects with 42 %; followed by placental or umbilical cord anomalies (28.9 %), skeletal defects (27.5), genitourinary anomalies (20.2 %), central nervous system (18.8 %) and facial anomalies (7.2 %), respectively. Eighty-five percent of the fetuses had at least one additional anomaly or ultrasound finding. Skeletal abnormalities and staged surgical repair of omphalocele were associated with survival. Associated skeletal anomalies and staged repair significantly increase the risk of postnatal death (OR: 4.6 95 % CI (1.1–19.5) and (OR: 10.3 95 % CI (1.6–63.9), respectively). Conclusions Associated skeletal abnormalities and staged surgical repair are negatively associated with postnatal survival.

Publisher

Walter de Gruyter GmbH

Subject

Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health

Reference20 articles.

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1. Überleben bei Omphalozele;Neonatologie Scan;2024-02-22

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