Determinants of prematurity in urban Indonesia: a meta-analysis
Author:
Marsubrin Putri Maharani Tristanita1, Ibrahim Naufal Arkan Abiyyu2ORCID, Dilmy Mohammad Adya Firmansha3, Ariani Yulia4, Wiweko Budi3, Irwinda Rima3, Harzif Achmad Kemal3, Hegar Badriul4, Basrowi Ray Wagiu5
Affiliation:
1. Department of Child Health, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital , Jakarta , Indonesia 2. Faculty of Medicine , Universitas Indonesia , Jakarta , Indonesia 3. Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital , Jakarta , Indonesia 4. Faculty of Medicine , Indonesian Medical Education and Research Institute, Universitas Indonesia , Jakarta , Indonesia 5. Danone Indonesia , Jakarta , Indonesia
Abstract
Abstract
Objectives
Indonesia is the fifth country with the highest number of preterm births worldwide. More than a third of neonatal deaths in Indonesia were attributed to preterm birth. Residential areas affected the occurrence of preterm birth due to differing socioeconomic and environmental conditions. Many studies have investigated the determinants of prematurity in Indonesia, however, most of them were performed in rural areas. This study is the first meta-analysis describing the determinants of preterm birth in urban Indonesia, which aimed to become the foundation upon implementing the most suitable preventative measure and policy to reduce the rate of preterm birth.
Methods
We collected all published papers investigating the determinants of preterm birth in urban Indonesia from PubMed MEDLINE and EMBASE, using keywords developed from the following key concepts: “preterm birth”, “determinants”, “risk factors”, “Indonesia” and the risk factors, such as “high-risk pregnancy”, “anemia”, “pre-eclampsia”, and “infections”. Exclusion criteria were multicenter studies that did not perform a specific analysis on the Indonesian population or did not separate urban and rural populations in their analysis, and articles not available in English or Indonesian. The Newcastle Ottawa Scale was used to assess the risk of bias. This systematic review was registered in PROSPERO.
Results
Sixteen articles were included in the analysis and classified into five categories: genetic factors, nutrition, smoking, pregnancy characteristics or complications, and disease-related characteristics.
Conclusions
Our meta-analysis revealed adolescent pregnancy, smoking, eclampsia, bacterial vaginosis, LC-PUFA, placental vitamin D, and several minerals as the significant determinants of preterm birth in urban Indonesia.
Publisher
Walter de Gruyter GmbH
Subject
Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health
Reference69 articles.
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