High mobility group box 1 in women with unexplained recurrent pregnancy loss-Reference-Cited by-同舟云学术

High mobility group box 1 in women with unexplained recurrent pregnancy loss

Published:2023-05-30 Issue:9 Volume:51 Page:1139-1146
ISSN:0300-5577
Container-title:Journal of Perinatal Medicine
language:en
Short-container-title:

Author:

Ticconi Carlo¹^ORCID,Mardente Stefania¹^ORCID,Mari Emanuela²,Barreca Federica²,Montanaro Manuela³^ORCID,Mauriello Alessandro³^ORCID,Rizzo Giuseppe⁴^ORCID,Zicari Alessandra²^ORCID

Affiliation:

1. Department of Surgical Sciences, Section of Gynecology and Obstetrics , University of Rome “Tor Vergata” , Rome , Italy

2. Department of Experimental Medicine , University of Rome “La Sapienza” , Rome , Italy

3. Department of Experimental Medicine , University of Rome “Tor Vergata” , Rome , Italy

4. Department of Biomedicine and Prevention, Section of Gynecology and Obstetrics , University of Rome “Tor Vergata” , Rome , Italy

Abstract

Abstract Objectives To investigate whether high mobility group box 1 (HMGB1) is involved in unexplained recurrent pregnancy loss (uRPL). Methods Plasma levels of HMGB1 were measured by ELISA in non-pregnant women with (n=44) and without (n=53 controls) uRPL. Their platelets and plasma-derived microvesicles (MVs) were also assayed for HMGB1. Endometrial biopsies were taken in selected uRPL (n=5) and control women (n=5) and the tissue expression of HMGB1 was determined by western blot and immunohistochemistry (IHC). Results plasma levels of HMGB1 were significantly higher in women with uRPL than in control women. HMGB1 content in platelets and MVs obtained from women with uRPL was significantly higher than that obtained from control women. HMGB1 expression in endometrium was higher in tissues obtained from women with uRPL than in tissues obtained from control women. IHC analysis revealed that HMGB1 is expressed in endometrium with different patterns between uRPL and control women. Conclusions HMGB1 could be involved in uRPL.

Publisher

Walter de Gruyter GmbH

Subject

Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health

Link

https://www.degruyter.com/document/doi/10.1515/jpm-2023-0109/pdf

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