A severe oxaliplatin immune-induced syndrome after oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Author:

Ezanno Anne-Cecile1ORCID,Malgras Brice1,Aoun Olivier2,Delarge Amaury3,Doreille Alice4,Pocard Marc5

Affiliation:

1. Department of Gastrointestinal and Endocrine Surgery , Bégin Military Hospital , St Mandé , France

2. 46th Medical Unit, 5th Armed Forces Medical Center , Strasbourg , France

3. Department of Acute Care Unit , Bégin Military Hospital , St Mandé , France

4. Department of Nephrology , Tenon Hospital , Paris , France

5. Department of Gastrointestinal and Cancerology , Pitié Salpetrière Hospital , Paris , France

Abstract

Abstract Objectives Oxaliplatin immune-induced syndrome (OIIS) was recently recognized as an uncommon complication of oxaliplatin therapy. Methods We report an exceptionally OIIS after pressurized intraperitoneal aerosol chemotherapy (PIPAC). Results Our patient developed a severe OIIS probably related to the intraperitoneal administration of oxaliplatin. Specific tests were performed and detected high-titer antibodies to oxaliplatin. Conclusions The OIIS is a rare. Physicians had to be aware of that clinical situation because it could be reversible, even in case of peritoneal advanced disease, and ICU treatment is justified.

Publisher

Walter de Gruyter GmbH

Subject

Internal Medicine

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