WDR74 promotes proliferation and metastasis in colorectal cancer cells through regulating the Wnt/β-catenin signaling pathway-Reference-Cited by-同舟云学术

WDR74 promotes proliferation and metastasis in colorectal cancer cells through regulating the Wnt/β-catenin signaling pathway

Published:2021-01-01 Issue:1 Volume:16 Page:920-929
ISSN:2391-5412
Container-title:Open Life Sciences
language:en
Short-container-title:

Author:

Cai Zhou¹,Mei Yan¹,Jiang Xiaoye¹,Shi Xingfeng²

Affiliation:

1. Department of Medical, Wuhan City College , Wuhan City , Hubei Province, 430083 , China

2. Department of Colorectal Surgery, The Ninth People’s Hospital of Chongqing , No. 69, Jialing Village, Beibei District , Chongqing City , 400700 , China

Abstract

Abstract Colon cancer (CRC) is a common type of cancer and has a high incidence worldwide. Protein 74 (WDR74), which consists of the WD repetition sequence, has been previously associated with tumor tumorigenesis. However, its mechanism of action in CRC remains unclear. Here, we found that WDR74 expression was upregulated in CRC tissues and cells. Downregulation of WDR74 repressed the proliferation and cell cycles in CRC cells. In addition, WDR74 knockdown induced cell apoptosis and suppressed both cell metastasis and invasion. Mechanistically, WDR74 decreased the phosphorylation of β-catenin and induced nuclear β-catenin accumulation, activating the Wnt/β-catenin signaling pathway in CRC cells. Further investigation showed that blocking the Wnt/β-catenin signaling pathway by XAV-939 reversed the effects of WDR74 on cell proliferation, migration, and invasion in HCT116 cells. Overall, WDR74 induced β-catenin translocation to the nucleus and activated the Wnt/β-Catenin, thus facilitated CRC cell proliferation and metastasis. In summary, WDR74 could be a potential target for the intervention of CRC.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/biol-2021-0096/pdf

Reference29 articles.

1. Yang Y, Han Z, Li X, Huang A, Shi J, Gu J. Epidemiology and risk factors of colorectal cancer in China. Chin J Cancer Res. 2020;32(6):729–41.

2. Zhang F, Zhang Y, Zhao W, Deng K, Wang Z, Yang C, et al. Metabolomics for biomarker discovery in the diagnosis, prognosis, survival and recurrence of colorectal cancer: a systematic review. Oncotarget. 2017;8(21):35460–72.

3. Croese A, Gartrell R, Hiscock R, Lee M, Gibbs P, Faragher I, et al. The effect of smoking, obesity and diabetes on recurrence-free and overall survival in patients with stage III colon cancer receiving adjuvant chemotherapy. Cancer Rep (Hoboken). 2021;e1346.

4. Padmanabhan C, Nussbaum DP, D’Angelica M. Surgical management of colorectal cancer liver metastases. Surg Oncol Clin N Am. 2021;30(1):1–25.

5. Ya Zhang XW. Targeting the Wnt/β-catenin signaling pathway in cancer. J Hematol Oncol. 2020;13(1):165.

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Wnt/β-catenin Signaling in Lung Cancer: Association with Proliferation, Metastasis, and Therapy Resistance;Current Cancer Drug Targets;2024-01

2. Curcumin promotes apoptosis of liver cancer cells by down-regulating WNT/β-catenin;Materials Express;2023-08-01

3. WDR74 serves as a novel therapeutic target by its oncogenic role in hepatocellular carcinoma;Pathology - Research and Practice;2023-08

4. Non-coding RNA-based therapeutics in cancer therapy: An emphasis on Wnt/β-catenin control;European Journal of Pharmacology;2023-07

5. WDR74 rs11231247 contributes to the susceptibility and prognosis of non-small cell lung cancer;Pathology - Research and Practice;2023-02