Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso-Reference-Cited by-同舟云学术

Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso

Published:2021-01-01 Issue:1 Volume:16 Page:1101-1110
ISSN:2391-5412
Container-title:Open Life Sciences
language:en
Short-container-title:

Author:

Zouré Abdou Azaque¹²³,Amegnona Lanyo Jospin¹,Zongo Nayi⁴,Kiendrebeogo Isabelle Touwendpoulimdé¹²,Sorgho Pegdwendé Abel¹²,Zongo Fabienne Ingrid¹²,Yonli Albert Théophane¹²,Sombié Herman Karim¹²,Bambara Aboubacar Hierrhum⁵,Sawadogo Alexis Yobi⁶,Ouedraogo Marie N. L.¹²⁷,Traoré Lassina¹²,Zongo Sidnooma Véronique¹²,Lallogo Doriane Tatiana¹²,Bazié Bapio Valery Jean Télesphore Elvira¹²,Zohoncon Théodora M.¹²⁷,Dijgma Florencia W.¹²,Simpore Jacques¹²

Affiliation:

1. Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso

2. Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso

3. Department of Biomedical and Public Health/Institute of Health Sciences Research, (IRSS/CNRST), Institute of Health Sciences Research , 03 BP 7192 , Ouagadougou 03 , Burkina Faso

4. Department of Surgery and Surgical Specialties, Service of General and Digestive Surgery, University Hospital Centre-Yalgado OUEDRAOGO, UFR/SDS, University Joseph KI-ZERBO , 03 BP 7021 , Ouagadougou 03 , Burkina Faso

5. Department of Medicine and Medical Specialties, Service of Oncology, University Hospital Centre-BOGODOGO, University Joseph KI-ZERBO, UFR/SDS , 03 BP 7021 , Ouagadougou 03 , Burkina Faso

6. Department of Gynecology-Obstetrics, Service of Gynecology, University Hospital Centre-BOGODOGO, University Joseph KI ZERBO, UFR/SDS , 03 BP 7021 , Ouagadougou 03 , Burkina Faso

7. Faculty of Medicine, University Saint Thomas d’Aquin , 06 BP 10212 , Ouagadougou 01 , Burkina Faso

Abstract

Abstract Several factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed breast cancer cases and 102 controls (cases without breast abnormalities). A multiplex polymerase chain reaction (PCR) was used to characterize the carriage of HLA-DRB1*11 and 1*12 alleles. The HLA-DRB1*11 allele was present in 26.59% of cases and 22.55% of controls. The HLA-DRB1*12 allele was present in 56.63% of cases and 55.88% of controls. This study found no direct association between the carriage of the HLA-DRB1*11 and HLA-DRB1*12 alleles and the occurrence of breast cancer. In addition, the deletion of the HLA-DRB1*11 allele is associated (beneficial effect) with obesity/overweight (OR = 0.13; 95% CI [0.01–1.14]; and p = 0.03) which is a risk for breast cancer. No direct association was found between the carriage of HLA-DRB1*11 and 1*12 alleles and breast cancer risk. However, further investigation of other HLA alleles involved in the occurrence of breast cancer may provide more information.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/biol-2021-0113/pdf

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