Correlation between peripheral blood lymphocyte subpopulations and primary systemic lupus erythematosus-Reference-Cited by-同舟云学术

Correlation between peripheral blood lymphocyte subpopulations and primary systemic lupus erythematosus

Published:2022-01-01 Issue:1 Volume:17 Page:839-845
ISSN:2391-5412
Container-title:Open Life Sciences
language:en
Short-container-title:

Author:

Feng Yan¹,Li Zhijun²,Xie Changhao²,Lu Fanglin¹

Affiliation:

1. Rheumatology Department, First Affiliated Hospital of Anhui University of Science and Technology , Huai Nan , China

2. Rheumatology Department, First Affiliated Hospital of Bengbu Medical College , Bangbu , China

Abstract

Abstract This study explored the correlation between peripheral blood CD3＋, CD3＋/CD4＋, CD3+/CD8+, CD4＋/CD8＋, CD3−/CD16+ CD56+, and CD3−CD19+ and disease activity of different subtypes of systemic lupus erythematosus (SLE). The percentages of CD3+, CD3+/CD4+, CD3+/CD8+, CD4+/CD8+, CD3−/CD16+ CD56+, and CD3−CD19+ in the peripheral blood of patients (n = 80) classified into lupus nephritis, blood involvement, and joint involvement and SLE in different active stages were detected by flow cytometry. Their correlations with baseline clinical experimental indicators of SLE patients’ SLE disease activity index score (SLEDAI) and complement C3 were analyzed. The results showed that CD3+, CD3+/CD4+, and CD3+/CD8+ at baseline level were negatively correlated with SLEDAI scores. These were positively correlated with C3. In conclusion, T-lymphocyte subpopulations are closely related to SLE activity and can be used as reference indicators to evaluate the SLE activity.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/biol-2022-0093/pdf

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