Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China-Reference-Cited by-同舟云学术

Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China

Published:2021-01-01 Issue:1 Volume:16 Page:150-159
ISSN:2391-5412
Container-title:Open Life Sciences
language:en
Short-container-title:

Author:

Zhuo Yafen¹,Ling Lin¹,Sun Zhichun¹,Huang Wensen²,Hong Zhenzhen¹,Zhang Yaping¹,Peng Xuefeng¹,Liu Xiaoyu³,Yuan Weilan⁴,Xu Wang-Yang⁵,Zhang Yi¹

Affiliation:

1. Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University , No. 250, East Street, Licheng District , Quanzhou , 362300, Fujian , China

2. Department of Internal Medicine, Quanzhou Medical College , Quanzhou , 362300 , China

3. Department of Oncology, Quanzhou First Hospital Affiliated to Fuji Medical University , Quanzhou , 362300 , China

4. Department of Information Technology, Biotecan Medical Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine , Shanghai , 201204 , China

5. Medical Department, Singlera Genomics Inc. , Lane 500, Furonghua Road, Pudong New District , Shanghai , 201318 , China

Abstract

Abstract The purpose of this study was to assess the relationship between 25-hydroxyvitamin D (25(OH)D), urinary iodine concentration (UIC), and type 2 diabetes mellitus (T2DM) risk and complications and to establish a model to predict T2DM in the general population. A total of 567 adults (389 T2DM patients and 178 controls) were enrolled, and the levels of 25(OH)D, iodine, and blood biochemical parameters were measured. Pearson’s correlation analysis showed an inverse correlation between 25(OH)D level, UIC, and T2DM risk. Low 25(OH)D level was a risk factor for developing T2DM (OR, 0.81; 95% CI, 1.90–2.63; P = 0.043) after adjustment for multiple risk factors. 25(OH)D level and UIC were inversely correlated with short-term and long-term glucose levels. 25(OH)D deficiency was also associated with a high incidence of T2DM complicated with thyroid dysfunction. A prediction model based on 25(OH)D, iodine status, and other risk factors was established and recommended to screen high-risk T2DM in the general population and provide early screening and timely treatment for them.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/biol-2021-0019/pdf

Reference39 articles.

1. Ma RCW. Epidemiology of diabetes and diabetic complications in China. Diabetologia. 2018;61:1249–60.

2. Wang L, Gao P, Zhang M, Huang Z, Zhang D, Deng Q, et al. Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA. 2017;317:2515–23.

3. Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care. 2011;34:1249–57.

4. DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, et al. Type 2 diabetes mellitus. Nat Rev Dis Prim. 2015;1:15019.

5. Moore WT, Bowser SM, Fausnacht DW, Staley LL, Suh KS, Liu D. Beta cell function and the nutritional state: dietary factors that influence insulin secretion. Curr Diabetes Rep. 2015;15:76.

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Vitamin D and the Thyroid: A Critical Review of the Current Evidence;International Journal of Molecular Sciences;2023-02-10

2. Does Iodine Influence the Metabolism of Glucose?;Medicina;2023-01-17