Role of MMP-2 and CD147 in kidney fibrosis

Author:

Cheng Zhengyuan1,Zhang Xiaojuan2,Zhang Yu3,Li Li3,Chen Pingsheng3

Affiliation:

1. Department of Internal Medicine, Ma’anshan People’s Hospital Affiliated to Medical School of Southeast University , Hubei Road 45, Huashan District , Ma’anshan 243099 , Anhui Province , China

2. Department of Nephrology, Jinling Hospital Affiliated to Nanjing University , Zhongshan East Road 305, Xuanwu District , Nanjing 210008 , Jiangsu Province , China

3. Department of Pathology and Pathophysiology, Medical School, Southeast University , Dingjiaqiao 87, Gulou District , Nanjing 210009 , Jiangsu Province , China

Abstract

Abstract Matrix metalloproteinase-2 (MMP-2) and cluster of differentiation 147 (CD147) both play important roles in the development of kidney fibrosis, and CD147 can induce the production and activation of MMP-2. In the early stage of kidney fibrosis, MMP-2 promotes extracellular matrix (ECM) production and accelerates the development of kidney fibrosis, while in the advanced stage, MMP-2 activity decreases, leading to reduced ECM degradation and making it difficult to alleviate kidney fibrosis. The reason for the decrease in MMP-2 activity in the advanced stage is still unclear. On the one hand, it may be related to hypoxia and endocytosis, which lead to changes in the expression of MMP-2-related active regulatory molecules; on the other hand, it may be related to insufficient CD147 function. At present, the specific process by which CD147 is involved in the regulation of MMP-2 activity is not completely clear, and further in-depth studies are needed to clarify the roles of both factors in the pathophysiology of kidney fibrosis.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

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