NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2-Reference-Cited by-同舟云学术

NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2

Published:2023-01-01 Issue:1 Volume:18 Page:
ISSN:2391-5412
Container-title:Open Life Sciences
language:en
Short-container-title:

Author:

Zhong Yuanping¹,Zhao Pengcheng¹,Zhang Chao¹,Wu Zhenyu¹,Fang Xu¹,Zhu Zhaoqiong²

Affiliation:

1. Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University , Zunyi City , Guizhou Province, 563000 , China

2. Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University , No. 149 Dalian Road, Huichuan District , Zunyi City , Guizhou Province, 563000 , China

Abstract

Abstract Postoperative cognitive dysfunction (POCD) is a common complication of cognitive decline after surgery and anesthesia. Sevoflurane, as a commonly used anesthetic, was found to cause POCD. Nudix Hydrolase 21 (NUDT21), a conserved splicing factor, has been reported to exert important functions in multiple diseases’ progression. In this study, the effect of NUDT21 on sevoflurane-induced POCD was elucidated. Results showed that NUDT21 was down-regulated in the hippocampal tissue of sevoflurane-induced rats. Morris water maze test results revealed that overexpression of NUDT21 improved sevoflurane-induced cognitive impairment. In addition, TUNEL assay results indicated that enhanced NUDT21 alleviated sevoflurane-induced apoptosis of hippocampal neurons. Furthermore, overexpression of NUDT21 suppressed the sevoflurane-induced LIMK2 expression. Taken together, NUDT21 alleviates sevoflurane-induced neurological damage in rats by down-regulating LIMK2, providing a novel target for the prevention of sevoflurane-induced POCD.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/biol-2022-0486/pdf

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