Ezrin promotes esophageal squamous cell carcinoma progression via the Hippo signaling pathway-Reference-Cited by-同舟云学术

Ezrin promotes esophageal squamous cell carcinoma progression via the Hippo signaling pathway

Published:2023-01-01 Issue:1 Volume:18 Page:
ISSN:2391-5412
Container-title:Open Life Sciences
language:en
Short-container-title:

Author:

Ma Lijuan¹,Liu Li²,Ji Min²,Su Liping²,Guan Yaling³,Xiao Jinling³,Pu Hongwei⁴

Affiliation:

1. State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Physiology, School of Basic Medical Sciences, Xinjiang Medical University , No. 567, Shangde North Road , Urumqi 830017, Xinjiang , China

2. Department of Pathology, First Affiliated Hospital, Xinjiang Medical University , No. 137, Liyushan South Road , Urumqi 830054, Xinjiang , China

3. Department of Pathology, School of Basic Medical Sciences, Xinjiang Medical University , No. 567, Shangde North Road , Urumqi 830017, Xinjiang , China

4. Department of Discipline Construction, First Affiliated Hospital, Xinjiang Medical University , No. 137, Liyushan South Road , Urumqi 830054, Xinjiang , China

Abstract

Abstract The aim of this study was to analyze the role of Ezrin in esophageal squamous cell carcinoma (ESCC) and investigate potential therapeutic targets for ESCC by interfering with Ezrin expression. Bioinformatics analysis revealed that Ezrin expression differed significantly among patients with different clinical stage ESCC. Moreover, there was a significant correlation between Ezrin and yes-associated protein/connective tissue growth factor (YAP1/CTGF) levels in esophageal cancer. Sixty paraffin-embedded ESCC tissue samples were examined and Ezrin and YAP1/CTGF levels were determined using immunohistochemistry. The positive expression rates of Ezrin and YAP1/CTGF were significantly lower in adjacent tissues than in ESCC tissues. Furthermore, knockdown of Ezrin expression inhibited colony formation and reduced cell migration and invasion. Compared with control ESCC cells, protein expression levels of YAP1 and CTGF were significantly downregulated in cells with Ezrin knocked down. We conclude that Ezrin may be involved in ESCC progression through the Hippo signaling pathway.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/biol-2022-0743/pdf

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