Meta-analysis of the rs231775 locus polymorphism in the CTLA-4 gene and the susceptibility to Graves’ disease in children-Reference-Cited by-同舟云学术

Meta-analysis of the rs231775 locus polymorphism in the CTLA-4 gene and the susceptibility to Graves’ disease in children

Published:2023-01-01 Issue:1 Volume:18 Page:
ISSN:2391-5412
Container-title:Open Life Sciences
language:en
Short-container-title:

Author:

Shi Mili¹,Liu Xiaobo²,Song Qiuyan¹,Shi Yijie¹,Tai Qirui¹

Affiliation:

1. Department of Pharmacy, People’s Hospital of Yuxi City , Yuxi , Yunnan 653100 , China

2. College of Pharmacy and Chemistry, Dali University , Dali , Yunnan 671000 , China

Abstract

Abstract The aim of this study was to systematically evaluate the correlation between the rs231775 locus polymorphism in the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene and genetic susceptibility to Graves’ disease (GD) in children. Some studies found that the CTLA-4 gene polymorphism was associated with GD in children. The data up to February 2022 were retrieved from the databases. Stata 15.0 software was used for meta-analysis. A total of seven studies were included in our research. The results of the meta-analysis showed that the rs231775 locus polymorphism in the CTLA-4 gene in general and Asian populations was correlated with children’s susceptibility to GD (A vs G: OR = 0.75, 95% CI (0.660–0.86); GG vs AA: OR = 1.34, 95% CI (1.04–1.73); AG vs AA: OR = 1.32, 95% CI (1.02–1.10); AG + GG vs AA: OR = 3.81, 95% CI (2.17–6.70); GG vs AA + AG: OR = 1.23, 95% CI (1.05–1.45)). In summary, the rs231775 locus polymorphism in the CLTA-4 gene may be a risk factor for GD in Asian children. The G allele may be a susceptibility factor, while the allele A may be a protective factor against GD in Asian children. In the future, more large-scale studies may be needed to verify our results.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/biol-2022-0589/pdf

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