Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model-Reference-Cited by-同舟云学术

Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model

Published:2021-01-01 Issue:1 Volume:16 Page:222-228
ISSN:2391-5412
Container-title:Open Life Sciences
language:en
Short-container-title:

Author:

Wang Junhao¹,Lou Zhaohui¹,Xi Haiyang¹,Li Zhi¹,Li Lepeng¹,Li Zhenzhen²,Zhang Kai¹,Asakawa Tetsuya³⁴

Affiliation:

1. Department of Orthopedic Surgery, First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan 450052 , China

2. Institute of Clinical Medicine, First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , China

3. Department of Neurosurgery, Hamamatsu University School of Medicine , Handayama, 1-20-1, Higashi-ku , Hamamatsu City , Shizuoka 431-3192 , Japan

4. Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine , Fuzhou 350122 , China

Abstract

Abstract Treatment of neuropathic pain is far from satisfactory. This study sought evidence of a neuroprotective effect of alpha-lipoic acid (ALA) to treat neuropathic pain in a chronic constriction injury (CCI) rat model. A total of 48 rats were randomly divided into sham, CCI, or CCI + ALA groups. Mechanical and thermal nociceptive thresholds were evaluated as behavioral assessments. Dorsal root ganglia cells were assessed morphologically with hematoxylin and eosin staining and for apoptosis with P53 immunohistochemical staining. Compared with the sham group, the CCI group had a shorter paw withdrawal threshold and paw withdrawal latency, abnormal morphologic manifestations, and increased numbers of satellite glial cells and P53+ cells. These changes were significantly reversed by treatment with ALA. Our study indicates neuroprotective effects of ALA on chronic neuropathic pain in a CCI rat model. ALA is potentially considered to be developed as a treatment for neuropathic pain caused by peripheral nerve injury, which requires further verification.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/biol-2021-0026/pdf

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