The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia
Author:
Affiliation:
1. Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei, 430022 , China
Abstract
Publisher
Walter de Gruyter GmbH
Subject
General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience
Link
https://www.degruyter.com/document/doi/10.1515/biol-2021-0121/pdf
Reference38 articles.
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2. Bleyer WA. The clinical pharmacology of methotrexate: new applications of an old drug. Cancer. 1978;41(1):36–51.
3. Giletti A, Esperon P. Genetic markers in methotrexate treatments. Pharmacogenomics J. 2018;18(6):689–703.
4. Zahra FT, Nahid NA, Islam MR, Al-Mamun MMA, Apu MNH, Nahar Z, et al. Pharmacogenetic variants in MTHFR gene are significant predictors of methotrexate toxicities in Bangladeshi patients with acute lymphoblastic leukemia. Clin Lymphoma Myeloma Leuk. 2020;20(2):E58–65.
5. Evans WE, Crom WR, Abromowitch M, Dodge R, Look AT, Bowman WP, et al. Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect. N Engl J Med. 1986;314(8):471–7.
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