A bio-engineering approach to generate bioinspired (spider) silk protein-based materials

Author:

Bargel Hendrik1,Scheibel Thomas12345

Affiliation:

1. Department of Biomaterials , 26523 University of Bayreuth , Prof.-Rüdiger-Bormann-Str. 1, 95447 Bayreuth , Germany

2. Bayreuth Center of Material Science and Engineering (BayMat) , Universitätsstr. 30, 95440 Bayreuth , Germany

3. Bavarian Polymer Institute (BPI) , Universitätsstr. 30, 95440 Bayreuth , Germany

4. Bayreuth Center of Colloids and Interfaces (BZKG) , Universitätsstr. 30, 95440 Bayreuth , Germany

5. 26523 Bayreuth Center for Molecular Biosciences (BZMB), University of Bayreuth , Universitätsstr. 30, 95440 Bayreuth , Germany

Abstract

Abstract Natural materials exhibit unique properties from the molecular to the macro scale. Utilizing biological engineering approaches, they can act as a blueprint for novel and sustainable solutions in material science and technology. This paper focuses on spider silks, exemplifying a high-performance biopolymeric fibrous material with exceptional mechanical properties, high biocompatibility, slow biodegradation, low immunogenicity, and, in some cases, microbe-repellent features. In-depth understanding of the molecular structure-function relationship has facilitated the development of engineered recombinant silk proteins. In combination with biomimetic processing, they can be used for technical as well as biomedical applications.

Publisher

Walter de Gruyter GmbH

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