An open-source research platform for mechanical ventilation based on Simulink® and STM32 nucleo

Author:

Röhren Felix1,von Platen Philip1,Lohse Arnhold1,Kniesburges Alexander1,Brütt Robin2,Leonhardt Steffen1,Walter Marian1

Affiliation:

1. Chair for Medical Information Technology , RWTH-Aachen University , Aachen , Germany

2. Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering , Lübeck , Germany

Abstract

Abstract Gain in knowledge in experimental fields of research is mostly achieved using commercial hardware platforms. The linked costs however can limit a broad access by scientists and in the specific case of mechanical ventilation the pandemic demonstrated that further and collective research is essential and necessary. This contribution presents the modular design and implementation of a research platform which is based on STM32 Nucleo boards and Simulink®. The hardware required such as the pneumatic circuit are covered as well as the software architecture in which clinician related settings are processed for control references. The core functionality of mandatory volume controlled (VCV) and pressure controlled ventilation (PCV) while ensuring a positive end-expiratory pressure for the patient ( PEEP ) $(\text{PEEP})$ is evaluated and the foundational software models are published in a repository.

Publisher

Walter de Gruyter GmbH

Reference13 articles.

1. M. Dar, L. Swamy, D. Gavin, and A. Theodore, “Mechanical-ventilation supply and options for the covid-19 pandemic. leveraging all available resources for a limited resource in a crisis,” Ann. Am. Thorac. Soc., vol. 18, no. 3, pp. 408–416, 2021. https://doi.org/10.1513/annalsats.202004-317cme.

2. J. M. Pearce, “A review of open source ventilators for covid-19 and future pandemics,” F1000Research, vol. 9, no. 9, p. 218, 2020. https://doi.org/10.12688/f1000research.22942.2.

3. Medicines & Healthcare products Regulatory Agency, “Specification for Ventilators to be used in UK Hospitals during the Coronavirus (Covid-19) Outbreak,” GOV.UK [Online]. Available at: https://www.gov.uk/government/publications/specification-for-ventilators-to-be-used-in-uk-hospitals-during-the-coronavirus-covid-19-outbreak Accessed: Mar. 20, 2020.

4. M. Walter, A. Stollenwerk, L. Eckstein, S. Kowalewski, and S. Leonhardt, “PV1000 – Interdisziplinäre Entwicklung eines Pandemie-Beatmungsgerätes,” in MT-2022 Tagungsband, 2022 [Online], p. 169. Available at: https://www.vdi-mechatroniktagung.de/images/programm/MT2022_Tagungsband.pdf.

5. Chairs of Medical Information Technology (MedIT) and Computer Science 11 – Embedded Software at RWTH Aachen University, “PV1000 – The People’s Ventilator: Lebensretter aus Aachen,” [Online]. Available at: https://www.pv1000.de/ Accessed: Oct. 27, 2023.

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