Synthesis of platinum(II) complexes of 2-cycloalkyl-substituted benzimidazoles and their cytotoxic effects-Reference-Cited by-同舟云学术

Synthesis of platinum(II) complexes of 2-cycloalkyl-substituted benzimidazoles and their cytotoxic effects

Published:2015-09-01 Issue:9-10 Volume:70 Page:243-250
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Özçelik A. Berna¹,Gümüş Fatma¹,Sağkan Rahşan Ilıkçı²,Muşabak Uğur²

Affiliation:

1. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Gazi University, 06330 Ankara, Turkey

2. Department of Immunology, Gulhane Military Medicinal Academia University, Ankara, Turkey

Abstract

Abstract Five novel Pt(II) complexes with some 2-cycloalkyl-substituted benzimidazole carrier-ligands were synthesized and evaluated for their in vitro cytotoxic activities against HeLa and OVCAR-3 cell lines. A cell viability test revealed that [dichloro-bis(2-cycloheptylbenzimidazole) platinum(II)] is less cytotoxic than cisplatin, and its cytotoxic effect can be compared with that of carboplatin. Flow cytometric analysis revealed that this complex at 117 μM concentration causes apoptosis in approx. 72 % of the OVCAR-3 cell population. In addition, the complex was found to cause an increase in the SubG1 population of both OVCAR-3 and HeLa cells and to cause less apoptosis in HeLa cells than cisplatin.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2014-4188/pdf

Reference32 articles.

1. Sadler PJ. Protein recognition of platinated DNA. Chem Bio Chem 2009;10:73–4.

2. Jakupec MA, Galanski M, Arion VB, Hartinger CG, Keppler BK. Antitumour metal compounds: more than theme and variations. Dalton Trans 2008;2:183–94.

3. Aris SM, Farrell NP. Towards antitumor active trans-platinum compounds. Eur J Inorg Chem 2009;1293–302.

4. Alderden RA, Hall MD, Hambley TW. The discovery and development of cisplatin. J Chem Educ 2006;5:728–34.

5. Lakomska I, Fandzloch M, Wietrzyk J. Structure-cytotoxicity relationship for different types of mononuclear platinum(II) complexes with 5,7-diterbutyl-1,2,4-triazolo[1,5-a]pyrimidine. J Inorg Biochem 2012;115:100–5.

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands;İstanbul Journal of Pharmacy;2023-12-28

2. Increase delivery, cytotoxicity, stability and induction of apoptosis in cisplatin by establishing a new complex with methotrexate;Journal of Drug Delivery Science and Technology;2023-09

3. CYTOTOXIC ACTIVITY STUDIES OF SOME PLATINUM(II) COMPLEXES WITH 2-SUBSTITUTEDBENZIMIDAZOLE LIGANDS;REV ROUM CHIM;2019

4. In Vitro Cytotoxic Activities of Platinum(II) Complex with 1-Methyl-2-(3'- hydroxypropyl)benzimidazole and 2-(3'-Hydroxypropyl)benzimidazolium Hexa- and Tetrachloroplatinate Salts;Letters in Drug Design & Discovery;2018-01-03