Alkaloid profiles and acetylcholinesterase inhibitory activities of Fumaria species from Bulgaria-Reference-Cited by-同舟云学术

Alkaloid profiles and acetylcholinesterase inhibitory activities of Fumaria species from Bulgaria

Published:2016-01-01 Issue:1-2 Volume:71 Page:9-14
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Vrancheva Radka Z.¹,Ivanov Ivan G.²,Aneva Ina Y.³,Dincheva Ivayla N.⁴,Badjakov Ilian K.⁴,Pavlov Atanas I.

Affiliation:

1. Department of Analytical Chemistry, University of Food Technologies, Plovdiv, 26 Maritza Blvd., 4002, Plovdiv, Bulgaria

2. Department of Organic Chemistry, University of Food Technologies, Plovdiv, 26 Maritza Blvd., 4002, Plovdiv, Bulgaria

3. Institute of Biodiversity and Ecosystem Research at the Bulgarian Academy of Science, 1113 Sofia, Bulgaria

4. AgroBioInstitute, Agricultural Academy, 8 Dr. Tsankov Blvd, 1000, Sofia, Bulgaria

Abstract

Abstract GC-MS analysis of alkaloid profiles of five Fumaria species, naturally grown in Bulgaria (F. officinalis, F. thuretii, F. kralikii, F. rostellata and F. schrammii) and analysis of acetylcholinesterase inhibitory activity of alkaloid extracts were performed. Fourteen isoquinoline alkaloids were identified, with the principle ones being protopine, cryptopine, sinactine, parfumine, fumariline, fumarophycine, and fumaritine. Protopine contents, defined by HPLC analysis varied between 210.6 ± 8.8 μg/g DW (F. schrammii) and 334.5 ± 7.1 μg/g DW. (F. rostellata). While all of the investigated alkaloid extracts significantly inhibited acetylcholinesterase activity, the F. kralikii demonstrated the highest level of inhibition (IC50 0.13 ± 0.01 mg extract/mL).

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2014-4179/pdf

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