Affiliation:
1. National Organization for Drug Control and Research, Cairo, Egypt
2. Faculty of Pharmacy for Girls, Pharmacognosy Department, Al-Azhar University, Nasr City, Cairo, Egypt
3. Faculty of Pharmacy, Pharmacognosy Department, Egyptian-Russian University, Cairo, Egypt
Abstract
Abstract
The hypolipidemic effect of an ethanolic extract from the roots and rhizomes of Panicum repens L. was investigated in rats suffering from high-cholesterol, diet-induced hyperlipidemia, and the phytochemicals in the extract were analyzed. The extract was administered p.o. in doses of 250 mg/kg/day together with cholesterol at a dose of 100 mg/kg/day for 7 weeks. The high-cholesterol diet caused a significant increase in total lipids, total cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and the atherogenic index, whereas the level of high-density lipoprotein cholesterol (HDL-C) was significantly decreased. Administration of the P. repens extract (p<0.05) significantly reduced the rise of the serum levels of total lipids, TC, TG, and LDL-C, as well as the atherogenic index, whereas it significantly increased (p<0.05) the level of HDL-C. HPLC analysis of the phenolics and flavonoids in the extract revealed the presence of gallic acid, chlorogenic acid, chicoric acid, primulic acid, rutin, apigenin-7-glucoside, and quercetin. In conclusion, the P. repens extract was found to possess hypolipidemic activity in high-fat, diet-induced hyperlipidemic rats.
Subject
General Biochemistry, Genetics and Molecular Biology
Reference23 articles.
1. Lusis AJ. Atherosclerosis. Nature 2000;407:233–41.
2. Saravanan R, Rajendra Prasad N, Pugalandi KV. Effect of Piper betle leaf extract on alcoholic toxicity in the rat brain. J Med Food 2003;6:261–5.
3. Moss JN, Dajani E. Antihyperlipidemic agents. In: Turner RA, Hebborn P, editors. Screening methods in toxicology. New York: Academic Press, Vol. 2, 1971:121.
4. Lal AA, Kumar T, Murthy PB, Pillai KS. Hypolipidemic effect of Coriandrum sativum L. in Triton-induced hyperlipidemic rats. Indian J Exp Biol 2004;42:909–12.
5. Belal EB, Khalafalla ME. Biodegradation of Panicum repens residues by Pleurotus ostreatus for its use as a non-conventional feed stuff in diets of Oreochromis niloticus. Afr J Microbiol Res 2011;5:3038–50.
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