Antibacterial and antifungal two phenolic sesquiterpenes from Dysoxylum densiflorum-Reference-Cited by-同舟云学术

Antibacterial and antifungal two phenolic sesquiterpenes from Dysoxylum densiflorum

Published:2019-10-10 Issue:1-2 Volume:75 Page:1-5
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Dharmayani Ni Komang T.¹,Yoshimura Tsuyoshi²,Hermawati Elvira³,Juliawaty Lia D.³,Syah Yana M.³

Affiliation:

1. Department of Chemistry, Faculty of Mathematics and Natural Sciences , Mataram University , Jalan Majapahit 62 , Mataram 83125 , Indonesia

2. Research Institute for Sustainable Humanosphere, Kyoto University , Uji, Kyoto 611-0011 , Japan

3. Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung , Jalan Ganesha 10 , Bandung 40132 , Indonesia

Abstract

Abstract A new phenolic sesquiterpene, dysoxyphenol (1), and the known sesquiterpene, 7R,10S-2-hydroxycalamenene (2), were isolated from the acetone extract of Dysoxylum densiflorum seeds. The structures of these compounds were determined based on physical, Nuclear Magnetic Resonance, and mass spectral data. Both compounds were evaluated for their antibacterial and antifungal properties against seven pathogenic bacteria and two wood-rotting fungi, respectively. The results showed that both compounds have significant antibacterial properties only against Bacillus subtilis (Minimum Inhibitory Concentration 28 μM), while in the antifungal evaluation compound 1 was found to be more active than compound 2. Therefore, compound 1 has promising antifungal properties that can be developed further for finding new antifungal agents.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2019-0072/pdf

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