Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp.-Reference-Cited by-同舟云学术

Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp.

Published:2019-08-06 Issue:11-12 Volume:74 Page:313-318
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Jeong Huijeong¹,Latif Abdul²,Kong Chang-Suk³^ORCID,Seo Youngwan¹,Lee Yeon-Ju⁴,Dalal Seema R.⁵,Cassera Maria B.⁵,Kingston David G.I.⁶

Affiliation:

1. Division of Marine Bioscience , Korea Maritime and Ocean University , Busan 49112 , Republic of Korea

2. Department of Chemistry , University of Malakand , Chakdara , Dir Lower, KP , Pakistan

3. Department of Food and Nutrition, College of Medical and Life Sciences , Silla University , Busan 46958 , Republic of Korea

4. Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology , Ansan 15627 , Republic of Korea

5. Department of Biochemistry and Molecular Biology, Center for Tropical and Emerging Global Diseases (CTEGD) , University of Georgia , Athens , GA 30602 , USA

6. Department of Chemistry, Virginia Tech Center for Drug Discovery , M/C 0212, Virginia Tech , Blacksburg , VA 24061 , USA

Abstract

Abstract Six known compounds, namely two halisulfates 1 and 2 and four epidioxy sterols 3–6, were isolated from the marine sponge Coscinoderma sp. The structures of these compounds were confirmed by nuclear magnetic resonance (1H and 13C NMR) spectroscopy, and their antiplasmodial activities were determined against the chloroquine-resistant Dd2 strain of Plasmodium falciparum. The epidioxy steroids 3–6 all showed moderate to weak antiplasmodial activity, with IC50 values of 2.7 μM for (24S)-5α,8α-epidioxy-24-methylcholesta-6-en-3β-ol (3), 11.6 μM for 5α,8α-epidioxycholesta-6,24(28)-dien-3β-o1 (4), 2.33 μM for 5α,8α-epidioxy-24-methylcholesta-6,9(11)-24(28)-trien-3β-ol (5), and between 12 and 24 μM for 5α,8α-epidioxycholesta-6-en-3β-ol (6). In contrast, halisulfate 2 (1) was inactive, and halisulfate 1 (2) had an of IC50 value of about 24 μM.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2019-0039/pdf

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