Bcl-2 family proteins: master regulators of cell survival-Reference-Cited by-同舟云学术

Bcl-2 family proteins: master regulators of cell survival

Published:2016-08-01 Issue:4 Volume:7 Page:259-270
ISSN:1868-503X
Container-title:Biomolecular Concepts
language:
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Author:

Hatok Jozef¹,Racay Peter²

Affiliation:

1. 1Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM CU), Biomedical Center Martin and Department of Medical Biochemistry JFM CU, Martin, Slovak Republic

2. 2Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM CU), Biomedical Center Martin and Department of Medical Biochemistry JFM CU, Mala Hora 4D, SK-03601 Martin, Slovak Republic

Abstract

AbstractThe most prominent function of proteins of the Bcl-2 family is regulation of the initiation of intrinsic (mitochondrial) pathways of apoptosis. However, recent research has revealed that in addition to regulation of mitochondrial apoptosis, proteins of the Bcl-2 family play important roles in regulating other cellular pathways with a strong impact on cell survival like autophagy, endoplasmic reticulum (ER) stress response, intracellular calcium dynamics, cell cycle progression, mitochondrial dynamics and energy metabolism. This review summarizes the recent knowledge about functions of Bcl-2 family proteins that are related to cell survival.

Publisher

Walter de Gruyter GmbH

Subject

Cellular and Molecular Neuroscience,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://www.degruyter.com/downloadpdf/journals/bmc/7/4/article-p259.xml

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