Affiliation:
1. 1Department of Virus Research and Vaccine Control, National Institute of Health, Gakuen, Musashimurayama, Tokyo 208, Japan
Abstract
Abstract A physiologically active substance has been isolated from Brazilian propolis and characterized as a new clerodane diterpenoid, as indicated by human hepatocellular carcinoma HuH 13 cell cytotoxicity assays. This compound inhibited growth of the hepatoma cells at a concentration around 10 μg/ml and arrested the tumor cells at S phase as revealed by flow cytometry. At higher concentrations it exerted lethal damage. The compound showed cytotoxicity on human lung carcinoma HLC-2, HeLa, KB and rat W3Y cells, whereas human diploid foreskin and primary rabbit kidney cells were less affected.
Subject
General Biochemistry, Genetics and Molecular Biology
Cited by
50 articles.
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