Further Halotyrosine Derivatives from the Marine Sponge Suberea aff. praetensa

Author:

Kijjoa Anake12,Watanadilok Rawiwan3,Sonchaeng Pichai3,Sawangwong Pichan4,Pedro Madalena2,Nascimento Maria São José2,Silva Artur M. S.5,Eaton Graham6,Herz Werner7

Affiliation:

1. Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, 4099-003 Porto, Portugal

2. Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia de Universidade do Porto, Rua Anibal Cunha, 4050-017 Porto Portugal

3. Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand

4. Department of Aquatic Science, Faculty of Sciences, Burapha University, Bangsaen, Chonburi 20131, Thailand

5. Departamento de Química, Universidade de Aveiro, 3810 Aveiro, Portugal

6. Department of Chemistry, University of Leicester, University Road, Leicester LE 7RH, UK

7. Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, FL 32306-4390, USA

Abstract

Reexamination of the marine sponge Suberea aff. praetensa, (Row) from the Gulf of Thailand furnished in addition to bromotyrosine derivatives found previously 5-bromo- and 5- chlorocavernicolin, cavernicolins 1 and 2, two other brominated tyrosine metabolites, a known bisoxazolidone and a new unusual rearranged tyrosine metabolite subereatensin. Several of the metabolites exhibited significant inhibitory effects against five human cancer cell lines.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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