<i>SLC25</i> family with energy metabolism and immunity in malignant tumors-Reference-Cited by-同舟云学术

SLC25 family with energy metabolism and immunity in malignant tumors

Published:2023-12-06 Issue:1 Volume:26 Page:65-77
ISSN:1765-2839
Container-title:Oncologie
language:en
Short-container-title:

Author:

Zhang Guiqian¹²³⁴,Wang Ning¹,Ma Shixun²³⁵,Wei Zhenhong⁵⁴,Tao Pengxian¹²³⁶⁵,Cai Hui¹²³⁵^ORCID

Affiliation:

1. First Clinical Medical College , Gansu University of Chinese Medicine , Lanzhou , China

2. Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province , Gansu Provincial Hospital , Lanzhou , China

3. General Surgery Clinical Medical Center, Gansu Provincial Hospital , Lanzhou , China

4. Cadre Ward of General Surgery Department , Gansu Provincial Hospital , Lanzhou , China

5. NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor , Gansu Provincial Hospital , Lanzhou , China

6. Institute of Clinical Medicine and Translational Medicine , Gansu Provincial People’s Hospital , Lanzhou , China

Abstract

Abstract Solute Carrier Family 25 (SLC25) is the largest family of mitochondrial membrane proteins in the human body, consisting of 53 members. Mitochondrial phosphate carriers (MPiC), cellular iron metabolism, voltage-dependent anion channels (VDAC), and oxidative phosphorylation in the SLC25 family play dominant roles in material transport, energy metabolism, etc. SLC25 family-related proteins are involved in the regulation of the progression of a variety of cancers, including colon, gastric, and lung cancers. In addition, the SLC25 family has been implicated in endoplasmic reticulum stress (ERS) and immunity. Since SLC25 family proteins are involved in cancer progression and are associated with endoplasmic reticulum stress and immunity, exploring inhibitors of SLC25 family-related proteins is essential. However, the exact mechanism of SLC25 family-related proteins involved in cancer, as well as potential targets and SLC25 inhibitors have not been reported in the literature. This article focuses on summarizing the relevance of the SLC25 family to cancer, ERS, and immunity. This review also provides a comprehensive overview of SLC25 family-related inhibitors.

Funder

Natural Science Foundation of Gansu Province

Gansu Provincial Youth Science and Technology Fund Program

National Health Commission Key Laboratory Master’s and Doctor’s Fund Programs

Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences

The 2021 Central-Guided Local Science and Technology Development Fund

Key talent project of Gansu Province of the Organization Department of Gansu Provincial Party Committee

Key project of science and technology innovation platform fund of Gansu Provincial People’s Hospital

Gansu Provincial People’s Hospital Excellent Master/PhD Student Incubation Program Project Fund

Postdoctoral Fund of Gansu Provincial People’s Hospital

Publisher

Walter de Gruyter GmbH

Subject

Oncology

Link

https://www.degruyter.com/document/doi/10.1515/oncologie-2023-0280/pdf

Reference128 articles.

1. Ziegler, M, Monné, M, Nikiforov, A, Agrimi, G, Heiland, I, Palmieri, F. Welcome to the family: identification of the NAD(+) transporter of animal mitochondria as member of the solute carrier family SLC25. Biomolecules 2021;11:880. https://doi.org/10.3390/biom11060880.

2. Ruprecht, J, Kunji, E. The SLC25 mitochondrial carrier family: structure and mechanism. Trends Biochem Sci 2020;45:244–58. https://doi.org/10.1016/j.tibs.2019.11.001.

3. Skinner, WM, Petersen, NT, Unger, B, Tang, S, Tabarsi, E, Lamm, J, et al.. Mitochondrial uncouplers impair human sperm motility without altering ATP content. Biol Reprod 2023;109:192–203. https://doi.org/10.1093/biolre/ioad064.

4. Zhang, Z, Qiao, Y, Sun, Q, Peng, L, Sun, L. A novel SLC25A1 inhibitor, parthenolide, suppresses the growth and stemness of liver cancer stem cells with metabolic vulnerability. Cell Death Discov 2023;9:350. https://doi.org/10.1038/s41420-023-01640-6.

5. Kunji, ERS, King, MS, Ruprecht, JJ, Thangaratnarajah, C. The SLC25 carrier family: important transport proteins in mitochondrial physiology and pathology. Physiology 2020;35:302–27. https://doi.org/10.1152/physiol.00009.2020.