MiR-100-5p transfected MSCs-derived exosomes can suppress NSCLC progression via PI3K-AKT-mTOR-Reference-Cited by-同舟云学术

MiR-100-5p transfected MSCs-derived exosomes can suppress NSCLC progression via PI3K-AKT-mTOR

Published:2023-10-16 Issue:6 Volume:25 Page:705-715
ISSN:1765-2839
Container-title:Oncologie
language:en
Short-container-title:

Author:

Wei Jing¹²,Chen Tianyu³,Feng Ganzhu¹^ORCID

Affiliation:

1. Department of Respiratory and Critical Care Medicine , The Second Affiliated Hospital of Nanjing Medical University , Nanjing , Jiangsu , China

2. Department of Respiratory and Critical Care Medicine , The Affiliated Sir Run Run Hospital of Nanjing Medical University , Nanjing , Jiangsu , China

3. Department of Respiratory and Critical Care Medicine , The Affiliated Taizhou People’s Hospital of Nanjing Medical University , Taizhou , Jiangsu , China

Abstract

Abstract Objectives Exosomes are highly implicated in lung cancer and are capable of transferring therapeutic miRNAs. Methods Database analysis was performed to screen the probable miRNA involved in non-small cell lung cancer (NSCLC). The levels of miR-100-5p in NSCLC cells and tissues were evaluated. The mechanism by which MSC-derived exosomes mediate the delivery of miR-100-5p in NSCLC cells was explored in vitro. The therapeutic effect and safety of miR-100-5p-containing MSC-derived exosomes in nude mice were assessed. Results MiR-100-5p was significantly downregulated in NSCLC. Transfer of miR-100-5p via MSCs-derived exosomes inhibited NSCLC progression by the PI3K-AKT-mTOR pathway. No obvious toxic effects were observed in mice. Conclusions MSCs-derived exosome-transfected miR-100-5p inhibits NSCLC progression via PI3K-AKT-mTOR, providing a promising diagnostic biomarker and therapeutic target of NSCLC.

Funder

Taizhou People’s Hospital Research Fund projectNone

Publisher

Walter de Gruyter GmbH

Subject

Oncology

Link

https://www.degruyter.com/document/doi/10.1515/oncologie-2023-0278/pdf

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