Affiliation:
1. The Second Hospital & Clinical Medical School , Lanzhou University , Lanzhou , China
2. Institute of Genetics, School of Basic Medical Sciences , Lanzhou University , Lanzhou , China
Abstract
Abstract
Gliomas are particularly challenging due to their high invasiveness, frequent recurrence, and elevated mortality rates. Despite the availability of treatments like surgery, radiation, and chemotherapy, each of these methods faces significant limitations. This has led to a pressing demand for new strategies against gliomas. In this landscape, mesenchymal stem cells (MSCs) have shown significant potential in recent years. However, the application of MSCs in glioma therapy encounters various challenges. A significant advancement in this field is the utilization of exosomes (Exo), key secretions of MSCs. These exosomes not only carry the benefits inherent in MSCs but also exhibit unique physicochemical properties that make them effective drug carriers. Consequently, MSCs Exo is gaining recognition as a sophisticated drug delivery system, specifically designed for glioma treatment. The scope of MSCs Exo goes beyond being just an innovative drug delivery mechanism; it also shows potential as a standalone therapeutic option. This article aims to provide a detailed summary of the essential role of MSCs Exo in glioma progression and its growing importance as a drug delivery carrier in the fight against this formidable disease.
Funder
NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Open Project
the Natural Science Foundation of Science and Technology Department of Gansu Province
the Gansu Province Health Industry Scientific Research Project
the Lanzhou City Chengguan District Science and Technology Project
the Natural Science Foundation of Gansu Provincial Department of Science and Technology
the National Natural Science Foundation of China
the “Cuiying Technology Innovation” Planning Project of Lanzhou University Second Hospital