Author:
Mackay Simon P.,O’Malley Patrick J.
Abstract
Abstract
Cyanoacrylate Inhibitors, Photosystem II, Hydrophobicity The secondary quinone binding site of photosystem II is also the binding site for many dif ferent herbicides. The 2-cyanoacrylate inhibitors are a potent class of electron transfer inhibitors which bind at this site and are extremely sensitive to minor structural variation. In order to understand their mode of binding, we have studied the interaction between the inhibitors and receptor in the D1 protein binding region (residues Leu 210 to Val 280) in terms of non bonded intermolecular forces. The intermolecular energy was calculated by van der Waals and electrostatic interactions after energy minimization of the combined structures to reduce inter and intramolecular strain. We have identified specific amino acid residues within the binding protein which are instrumental in binding the herbicide and have shown that the spatial arrangement of the herbicide functional groups within the binding site rather than their lipophilicity is the determining factor in binding efficiency.
Subject
General Biochemistry, Genetics and Molecular Biology
Cited by
9 articles.
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