Shaping the CD4+ memory immune response against tuberculosis: the role of antigen persistence, location and multi-functionality-Reference-Cited by-同舟云学术

Shaping the CD4+ memory immune response against tuberculosis: the role of antigen persistence, location and multi-functionality

Published:2012-02-01 Issue:1 Volume:3 Page:13-20
ISSN:1868-503X
Container-title:BioMolecular Concepts
language:
Short-container-title:

Author:

Ancelet Lindsay¹,Kirman Joanna¹

Affiliation:

1. 1Infectious Diseases Group, Malaghan Institute of Medical Research, Wellington, New Zealand

Abstract

AbstractEffective vaccination against intracellular pathogens, such as tuberculosis (TB), relies on the generation and maintenance of CD4 memory T cells. An incomplete understanding of the memory immune response has hindered the rational design of a new, more effective TB vaccine. This review discusses how the persistence of antigen, the location of memory cells, and their multifunctional ability shape the CD4 memory T cell response against TB.

Publisher

Walter de Gruyter GmbH

Subject

Cellular and Molecular Neuroscience,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://www.degruyter.com/downloadpdf/journals/bmc/3/1/article-p13.xml

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