Human aldo-keto reductases: structure, substrate specificity and roles in tumorigenesis-Reference-Cited by-同舟云学术

Human aldo-keto reductases: structure, substrate specificity and roles in tumorigenesis

Published:2011-04-01 Issue:1-2 Volume:2 Page:115-126
ISSN:1868-503X
Container-title:BioMolecular Concepts
language:
Short-container-title:

Author:

Ma Jun¹,Cao Deliang¹

Affiliation:

1. 1Department of Medical Microbiology, Immunology and Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, 913 N. Rutledge Street, Springfield, IL 62794, USA

Abstract

AbstractThe aldo-keto reductase (AKR) superfamily consists of over 150 protein members sharing similar structure and enzymatic activities. To date, 13 human AKRs have been identified, and they participate in xenobiotic detoxification, biosynthesis and metabolism. Increasing evidence suggests the involvement of human AKR proteins in cancer development, progression and treatment. Some proteins demonstrate multiple functional features in addition to being a reductase for carbonyl groups. This review article discusses the most recent progress made in the study of humans AKRs.

Publisher

Walter de Gruyter GmbH

Subject

Cellular and Molecular Neuroscience,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://www.degruyter.com/downloadpdf/journals/bmc/2/1-2/article-p115.xml

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