Affiliation:
1. 1Albacete Science and Technology Park, Regional Center for Biomedical Research (C.R.I.B.) at the University of Castilla-La Mancha, C/Almansa 14, 02006 Albacete, Spain
Abstract
AbstractTheSchlafengenes have been associated with proliferation control and with several differentiation processes, as well as with disparate phenotypes such as immune response, embryonic lethality and meiotic drive. They constitute a gene family with widespread distribution in mammals, where they are expressed in several tissues, predominantly those of the immune system. Moreover, horizontal transfer of these genes to orthopoxviruses suggests a role of the viralSchlafensin evasion to the host immune response. The expression and functional studies of this gene family will be reviewed under the prism of their evolution and diversification, the challenges they pose and the future avenues of research.
Subject
Cellular and Molecular Neuroscience,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
19 articles.
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