Detection capacity of small intestine bacterial or methanogen overgrowth by lactose and fructose breath testing in the adult population-Reference-Cited by-同舟云学术

Detection capacity of small intestine bacterial or methanogen overgrowth by lactose and fructose breath testing in the adult population

Published:2024-08-09 Issue:3 Volume:5 Page:327-332
ISSN:2628-491X
Container-title:Advances in Laboratory Medicine / Avances en Medicina de Laboratorio
language:en
Short-container-title:

Author:

Laserna Mendieta Emilio José¹²³⁴⁵^ORCID,Martín Dominguez Verónica³⁶^ORCID,Pérez Lucendo Irene²^ORCID,Granero Cremades Inmaculada²,Ferreirós Martínez Raquel²^ORCID,Álvarez Malé Tomás³⁶^ORCID,Sanz De Benito María Ángeles²,Santander Cecilio³⁵⁶⁷^ORCID

Affiliation:

1. Gastroenterology Research Unit , Hospital General de Tomelloso , Tomelloso , Ciudad Real , Spain

2. Service of Clinical Laboratory , Hospital Universitario La Princesa , Madrid , Spain

3. Instituto de Investigación Sanitaria La Princesa , Madrid , Spain

4. Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM) , Toledo , Spain

5. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) , Madrid , Spain

6. Department of Gastroenterology , Hospital Universitario La Princesa , Madrid , Spain

7. Department of Medicine , Universidad Autónoma de Madrid , Madrid , Spain

Abstract

Abstract Objectives Exhaled breath tests (BTs) are the main diagnostic method for fructose and lactose malabsorption/intolerance (FI and LI, respectively) and for detecting small intestine bacterial or methanogen overgrowth (SIBO/IMO). Although FI/LI-BTs may provide evidence of the presence of SIBO/IMO, there is limited literature evaluating their reliability for this purpose. The objective of this study was to assess the sensitivity and specificity of FI/LI-BTs in detecting SIBO and their concordance with SIBO-BTs in the identification of IMO. Methods In this retrospective observational study, FI/LI-BTs and SIBO-BTs performed in the same patients within a period of 6 weeks were selected from 652 gas chromatography-based BTs. Results A total of 146 BTs from 67 eligible adult patients were identified. LI-BTs had higher specificity than FI-BT in detecting SIBO (93.8 % vs. 72.7 %). In contrast, FI-BTs showed higher sensitivity (60.0 % vs. 28.6 %) as FI was more frequently established in SIBO-positive patients (70 % vs. 29 %). With regard to IMO, concordance with LI-BT was 100 %, with a 27 % of false negatives on FI-BTs. Conclusions Findings suggestive of SIBO or IMO on LI-BTs were highly consistent with those of SIBO-BTs. In contrast, the rate of false positives for SIBO and the rate of false negative for IMO on FI-BTs was 27 % in both cases.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/almed-2024-0115/pdf

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