Control of occult hepatitis B virus infection-Reference-Cited by-同舟云学术

Control of occult hepatitis B virus infection

Published:2022-08-15 Issue:4 Volume:3 Page:321-330
ISSN:2628-491X
Container-title:Advances in Laboratory Medicine / Avances en Medicina de Laboratorio
language:en
Short-container-title:

Author:

Lalana Garcés Marta¹²,Ortiz Pastor Oihana¹³,Solé Enrech Gemma¹⁴,Guerra-Ruiz Armando R.¹⁵^ORCID,Casals Mercadal Gregori¹⁶,Almería Lafuente Alejandro¹⁷,Ballesteros Vizoso María Antonieta¹⁸,Medina Pablo Gabriel¹⁹,Salgüero Fernández Sergio¹¹⁰^ORCID,Zamora Trillo Angielys¹¹¹,Aured de la Serna Isabel¹²,Hurtado Juan Carlos¹³¹⁴,Pérez-Del-Pulgar Sofía¹⁵,Forns Xavier¹⁵,Morales Ruiz Manuel¹⁶¹⁶

Affiliation:

1. Comisión de Valoración Bioquímica de la Enfermedad Hepática, Sociedad Española de Medicina de Laboratorio (SEQC-ML) , Barcelona , Spain

2. Servicio de Análisis Clínicos, Hospital de Barbastro , Huesca , Spain

3. Servicio de Bioquímica Clínica, Hospital Universitario Miguel Servet , Zaragoza , Spain

4. Servei de laboratori, UDIAT-CD, Corporació Sanitaria Parc Taulí , Sabadell , Spain

5. Servicio de Análisis Clínicos, Hospital Universitario Marqués de Valdecilla , Santander , Spain

6. Servicio de Bioquímica y Genética Molecular, CDB, Hospital Clínic de Barcelona, IDIBAPS, CIBEREHD , Barcelona , Spain

7. Servicio de Bioquímica Clínica, Hospital Royo Villanova , Zaragoza , Spain

8. Servicio de Análisis Clínicos, Hospital Universitario Son Espases , Palma de Mallorca , Spain

9. Servicio de Bioquímica Clínica, Hospital Universitari Vall d’Hebron , Barcelona , Spain

10. Servicio de Análisis Clínicos, Hospital Universitario Fundación Alcorcón , Madrid , Spain

11. Servicio de Bioquímica Clínica, Hospital General Universitario Gregorio Marañón , Madrid , Spain

12. Servicio de Digestivo, Hospital de Barbastro , Huesca , Spain

13. Servicio de Microbiología, CDB, Hospital Clínic de Barcelona, Universitat de Barcelona , Barcelona , Spain

14. Instituto de Salud Global de Barcelona (ISGlobal) , Barcelona , Spain

15. Servicio de Hepatología, Hospital Clínic de Barcelona, IDIBAPS, CIBEREHD , Barcelona , Spain

16. Departamento de Biomedicina de la Facultad de Medicina y Ciencias de la Salud-Universidad de Barcelona , Barcelona , Spain

Abstract

Abstract Background The diagnosis of hepatitis B virus (HBV) infection requires HBV DNA testing and serologic testing for detection of the surface antigen (HBsAg) and the hepatitis B core antibody (anti-HBc). There is a population of patients with occult HBV infection (OBI), which is not detected by HBsAg or HBV DNA quantification in blood, despite the presence of active replication in the liver. Scope This document provides a definition of OBI and describes the diagnostic techniques currently used. It also addresses the detection of patients with risk factors and the need for screening for OBI in these patients. Summary Correct diagnosis of OBI prevents HBV reactivation and transmission. Diagnosis of OBI is based on the detection of HBV DNA in patients with undetectable HBsAg in blood. Perspectives A high number of patients with OBI may remain undiagnosed; therefore, screening for OBI in patients with factor risks is essential. For a correct diagnosis of OBI, it is necessary that new markers such as ultrasensitive HBsAg are incorporated, and a more comprehensive marker study is performed by including markers such as cccDNA.

Funder

Ministry of Economy and Competitiveness

CIBERehd

Publisher

Walter de Gruyter GmbH

Subject

Medical Laboratory Technology,Education,Medicine (miscellaneous)

Link

https://www.degruyter.com/document/doi/10.1515/almed-2022-0065/pdf

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