Recommendations for the measurement of sexual steroids in clinical practice. A position statement of SEQC<sup>ML</sup>/SEEN/SEEP-Reference-Cited by-同舟云学术

Recommendations for the measurement of sexual steroids in clinical practice. A position statement of SEQC^ML/SEEN/SEEP

Published:2023-03-01 Issue:1 Volume:4 Page:52-60
ISSN:2628-491X
Container-title:Advances in Laboratory Medicine / Avances en Medicina de Laboratorio
language:en
Short-container-title:

Author:

Casals Gregori¹,Costa Roser Ferrer²,Rull Eulàlia Urgell³,Escobar-Morreale Héctor F.⁴,Argente Jesús⁵^ORCID,Sesmilo Gemma⁶,Biagetti Betina⁷

Affiliation:

1. Servicio de Bioquímica y Genética Molecular, Hospital Clínic, IDIBAPS , CIBEREHD Universidad de Barcelona , Barcelona , Spain

2. Servicio de Bioquímica, Laboratoris Clínics , Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona , Barcelona , Spain

3. Servicio de Bioquímica , Hospital de la Santa Creu i Sant Pau , Barcelona , Spain

4. Servicio de Endocrinología y Nutrición , Hospital Ramón y Cajal, Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS y CIBER Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM , Madrid , Spain

5. Departamento de Pediatría y Endocrinología Pediátrica , Hospital Infantil Universitario Niño Jesús, Universidad Autonoma de Madrid, CIBEROBN, Instituto de Salud Carlos III , Madrid , Spain

6. Servicio de Endocrinología y Nutrición , Hospital Universitari Dexeus , Barcelona , Spain

7. Servicio de Endocrinología y Nutrición , Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona , Barcelona , Spain

Abstract

Abstract The proper clinical approach to a wide range of disorders relies on the availability of accurate, reproducible laboratory results for sexual steroids measured using methods with a high specificity and sensitivity. The chemiluminescent immunoassays currently available have analytical limitations with significant clinical implications. This position statement reviews the current limitations of laboratory techniques for the measurement of estradiol and testosterone and their impact on diverse clinical scenarios. A set of recommendations are provided to incorporate steroid hormone analysis by mass spectrometry in national health systems. International societies have recommended this methodology for a decade.

Publisher

Walter de Gruyter GmbH

Subject

Medical Laboratory Technology,Education,Medicine (miscellaneous)

Link

https://www.degruyter.com/document/doi/10.1515/almed-2023-0020/pdf

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