Osteocalcin associates with bone mineral density and <i>VDR</i> gene polymorphisms in type 1 and type 2 diabetes-Reference-Cited by-同舟云学术

Osteocalcin associates with bone mineral density and VDR gene polymorphisms in type 1 and type 2 diabetes

Published:2023-10-24 Issue:0 Volume:0 Page:
ISSN:2628-491X
Container-title:Advances in Laboratory Medicine / Avances en Medicina de Laboratorio
language:en
Short-container-title:

Author:

Ramírez Ruiz Carla¹²,Varo Cenarruzabeitia Nerea³,Martínez Villanueva Miriam⁴,Hernández Martínez Antonio M.⁵,Noguera Velasco José Antonio⁵

Affiliation:

1. Department of Clinical Biochemistry , Clínica Universidad de Navarra , Madrid , Spain

2. Servicio de Bioquímica, Clínica Universidad de Navarra – Madrid , Madrid , Spain

3. Department of Clinical Biochemistry , Clínica Universidad de Navarra , Pamplona , Spain

4. Department of Clinical Biochemistry , Hospital Clínico Universitario Virgen de la Arrixaca , Murcia , Spain

5. Endocrinology and Nutrition Department , Hospital Clínico Universitario Virgen de la Arrixaca , Murcia , Spain

Abstract

Abstract Objectives Bone metabolism is impaired in diabetes mellitus (DM). Our objective is to evaluate the association of bone turnover markers (BTM) and vitamin D receptor (VDR) gene polymorphisms with bone mineral density (BMD) in DM type 1 (T1D) and DM type 2 (T2D). Methods 165 patients (53 T1D and 112 T2D) were enrolled. BMD was measured by dual-energy X-ray absorptiometry (DEXA). Plasma osteocalcin (OC), beta-CrossLaps (β-CTX) and N‐amino terminal propeptide of type I collagen (P1NP) and VDR gene polymorphisms were evaluated. Results Participants were 53 T1D (41 years [31–48]) and 112 T2D (60 years [51–66]). BMD were not statistically different between the groups. OC (p<0.001) and P1NP levels (p<0.001) were higher in patients with T1D. The areas under the curve for the prediction of bone pathology were 0.732 (p=0.038) for OC in T1D and 0.697 (p=0.007) in T2D. A significant association was found between lower lumbar BMD and the A allele of BsmI (p=0.03), the A allele of ApaI (p=0.04) and the allele C of the Taql (p=0.046). Also, a significant correlation was found with higher OC levels and the G allele of BsmI (p=0.044), C allele of ApaI (p=0.011), T allele of Taql (p=0.006) and with C allele of FokI (p=0.004). Conclusions The high negative predictive value of the cut-off point for OC suggests that could be useful in excluding the risk suffering bone loss, allowing offering a personalized clinical approach to prevent this pathology.

Publisher

Walter de Gruyter GmbH

Subject

Medical Laboratory Technology,Education,Medicine (miscellaneous)

Link

https://www.degruyter.com/document/doi/10.1515/almed-2023-0131/pdf

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