An opportunity to emphasize the relevance of laboratory medicine

Author:

Santamaría González María12,Ruiz Mínguez María Ángels23,Arrebola Ramírez María Monsalud24,Filella Pla Xavier256,Torrejón Martínez María José27,Morell García Daniel28,Castaño López Miguel Ángel29,Allué Palacín Juan Antonio210,Albaladejo Otón María Dolores211,Giménez Gómez Nuria212136ORCID

Affiliation:

1. Service of Clinical Biochemistry, Miguel Servet University Hospital , Zaragoza , Spain

2. Commission of Evidence-Based Laboratory Medicine, Spanish Society of Laboratory Medicine (SEQC ) , Barcelona , Spain

3. Service of Laboratory Medicine, Fundació Hospital de l’Esperit Sant, Santa Coloma de Gramenet , Barcelona , Spain

4. Laboratory Clinical Management Unit, Hospital de la Axarquía (AGSEMA) , Málaga , Spain

5. Service of Biochemistry and Molecular Genetics (CDB), Hospital Clinic, IDIBAPS , Barcelona , Spain

6. Commission of Evidence-Based Laboratory Medicine, International Federation of Clinical Chemistry (IFCC) , Milan , Italy

7. Clinical Biochemistry Management Unit (UGC), Hospital Clínico San Carlos , Madrid , Spain

8. Service of Laboratory Medicine, Hospital Universitari Son Espases , Palma de Mallorca , Spain

9. Service of Clinical Biochemistry, Hospital Clínico Universitario Juan Ramón Jiménez , Huelva , Spain

10. Synlab Diagnosticos Globales , Sevilla , Spain

11. Service of Laboratory Testing and Clinical Biochemistry, Santa Lucía University Hospital , Cartagena , Spain

12. Research Unit, Research Foundation, Mutua de Terrassa, University of Barcelona , Barcelona , Spain

13. Laboratory of Toxicology, Universitat Autònoma de Barcelona , Barcelona , Spain

Abstract

Abstract Objectives Clinical practice guidelines (CPGs) are recommendations based on a systematic review of scientific evidence that are intended to help healthcare professionals and patients make the best clinical decisions. CPGs must be evidence-based and are designed by multidisciplinary teams. The purpose of this study is to assess the topics related to the clinical laboratory addressed in CPGs and evaluate the involvement of laboratory professionals in the CPG development process. Methods A total of 16 CPGs recommended by the Spanish Society of Laboratory Medicine and/or retrieved from PubMed-Medline were included. A review of the information provided in CPGs about 80 topics related to the clinical laboratory was performed. The authorship of laboratory professionals was assessed. Results On average, the 16 CPGs addressed 49% (standard deviation [SD]: 11%) of the topics evaluated in relation to the clinical laboratory. By order of frequency, CPGs contained information about 69% of postanalytical variables (SD: 20%); 52% of preanalytical variables (SD: 11%); and 43% of the analytical variables studied (SD: 18%). Finally, half the CPGs included a laboratory professional among its authors. Conclusions CPGs frequently failed to provide relevant laboratory-related information. Laboratory professionals were co-authors in only half the CPGs. There is scope for improvement, and laboratory professionals should be included in multidisciplinary teams involved in the development of CPGs.

Publisher

Walter de Gruyter GmbH

Reference37 articles.

1. Institute of Medicine (U.S.A). Committee on standards for developing trustworthy clinical practice guidelines. In: Graham, R, Mancher, M, Wolman, DM, Greenfield, S, Steinberg, E, editors. Clinical practice guidelines we can trust. Washington, D.C.: The National Academies Press; 2011. Available from: http://www.nap.edu/read/13058/chapter/1 [Accessed 6 Jul 2020].

2. Djulbegovic, B, Guyatt, G. Evidence vs consensus in clinical practice guidelines. J Am Med Assoc 2019;322:725–6. https://doi.org/10.1001/jama.2019.9751.

3. Rabi, DM, Kunneman, M, Montori, VM. When guidelines recommend shared decision-making. J Am Med Assoc 2020;323:1345–6. https://doi.org/10.1001/jama.2020.1525.

4. Gracia García, S, Giménez Gómez, N, Ruiz Mínguez, A. Medicina basada en la evidencia – guías de práctica clínica. Bioquímica Patol Clínica 2006;69:34–7.

5. Florkowski, C, Don-Wauchope, A, Gimenez, N, Rodriguez-Capote, K, Wils, J, Zemlin, A. Point-of-care testing (POCT) and evidence-based laboratory medicine (EBLM) – does it leverage any advantage in clinical decision making? Crit Rev Clin Lab Sci 2017;54:471–94. https://doi.org/10.1080/10408363.2017.1399336.

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