Dialiumoside, an Olean-18-ene Triterpenoid from Dialium excelsum

Abstract

Phytochemical investigation of the stem bark and fruits of Dialium excelsum led to the isolation of a new triterpenoid, named dialiumoside (1), together with twelve known compounds (2 - 13). The structure of the new compound as well as those of the known compounds were established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1 - 13 were tested for their cytotoxic activity against the human cervix carcinoma KB-3-1 cells and the related multi drug-resistant P-gp-expressing KB-V1 cells. Compounds 1 and 13 showed weak biological activity in cytotoxicity assays while other compounds were inactive.