Effects of zinc supplementation on oxidant/antioxidant and lipids status of pesticides sprayers

Abstract

AbstractBackgroundExcess exposure to pesticides induces oxidative stress and causes alteration in the lipid profileObjectivesThe study aimed to evaluate the effects of Zinc (Zn) supplementation on the oxidant/antioxidant and lipid status in pesticide sprayers.MethodsForty pesticide sprayers were included in the study. Blood lipids, malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and Zn were estimated; before and after Zn supplementation.ResultsStatistical analysis revealed that after Zn supplementation, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and MDA were significantly decreased. However, there was a significant increase in the high density lipoprotein (HDL), SOD, GPx, and Zn levels. After Zn supplementation, significant inverse correlations were detected between the Zn and the levels of MDA, TG, and VLDL, while positive correlation between Zn and the levels of HDL and TC.ConclusionsZn supplementation improves the oxidative/antioxidants and lipid status in pesticide sprayers.