Novel Selective 5-HT3 Receptor Ligands: Facile Generation Methods for 2-Amino- and 4-Aminopyrido[4’,3’:4,5]thieno[2,3-d]pyrimidines

Abstract

This work reports on the synthesis of new 2-amino- and 4-aminopyridothienopyrimidines, with a view to identify potent and selective ligands for the 5-HT3 receptor, starting from derivatives of 2-aminothiophene-3-carboxylic ester, -3-carboxamide, or 2-amino-3-cyanothiophene.