Author:
Chetrite Gérard S.,Pasqualini Jorge R.
Abstract
Abstract: The progestogen nomegestrol acetate (NOMAC), a 17α-hydroxy-nor-progesterone derivative (LUTENYL: Cells were incubated with physiological concentrations of androgen substrates [: Aromatase activity levels are high in MCF-7aro cells because the [: The MCF-7aro cell line shows high aromatase activity and NOMAC can act as an anti-aromatase agent by inhibiting this activity. This is an important new effect of this progestogen. Because NOMAC can also inhibit sulfatase activity in breast cancer cells, we suggest that this dual effect of NOMAC has attractive possibilities for clinical trials.
Subject
Endocrinology,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
5 articles.
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