Natural tyrosinase inhibitors from Betula platyphylla barks

Author:

Shu Peng-Hua1,Zhang Hui1,Li Nian-Ci1,Zhang Jia-Long1,Liu Guang-Wei1,Yang Yuan1,Zang Shuo1,Cai Shu-Jing1,Wei Xia-Lan2,Sun Na1,Xiao Fu-Gang1

Affiliation:

1. Food and Pharmacy College , Xuchang University , 88 Bayi Road , Xuchang , Henan 461000 , P. R. China

2. School of Information Engineering , Xuchang University , 88 Bayi Road , Xuchang , Henan 461000 , P. R. China

Abstract

Abstract During the process of searching for tyrosinase inhibitors from natural medicines, one new monoterpene rhamnoside (1) and 13 known compounds (214) were isolated from the ethanolic extract of Betula platyphylla barks by repeated column chromatography. These structures were identified by comprehensive spectroscopic data analysis such as high-resolution electrospray ionization mass spectra (HR-ESI-MS), nuclear magnetic resonance (NMR), optical rotatory dispersion (ORD) and acid hydrolysis. In vitro assay revealed that compounds 6, 7 and 14 showed obvious inhibitory activity against tyrosinase.

Publisher

Walter de Gruyter GmbH

Subject

Biomaterials

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