Affiliation:
1. Fachbereich Biochemie Christian-Albrechts-Universität zu Kiel Rudolf-Höber Strasse 1, 24118 Kiel Kiel Germany
Abstract
Abstract
Lysosomes are cellular organelles that are important for the degradation and recycling of various biomolecules. Specialized lysosomal membrane proteins, as well as soluble enzymes, are important for the efficient turn-over of lysosomal substrates. A deficiency in the degradative capacity of lysosomes leads to severe pathologies referred to as lysosomal storage disorders. There is increasing evidence for the importance of lysosomal function in neurodegenerative disorders, including Parkinson’s disease. One reason for this might be the vulnerability of neuronal cells. Since neurons do not undergo further cell division, non-degraded substrates accumulate in aging cells, causing a buildup of toxicity. Recent genomic screenings identified a number of lysosome-associated genes as potential risk factors for Parkinson’s disease, which are discussed in this review. Moreover, it is outlined how targeting lysosomal function might help in developing novel therapeutic strategies.
Subject
Neurology (clinical),Neurology
Reference58 articles.
1. Baba, M., Nakajo, S., Tu, P.H., Tomita, T., Nakaya, K., Lee, V.M., Trojanowski, J.Q., and Iwatsubo, T. (1998). Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson’s disease and dementia with Lewy bodies. Am. J. Pathol. 152, 879–884.
2. Bainton, D.F. (1981). The discovery of lysosomes. J. Cell Biol. 91, 66s–76 s.
3. Bar-On, P., Rockenstein, E., Adame, A., Ho, G., Hashimoto, M., and Masliah, E. (2006). Effects of the cholesterol-lowering compound methyl-β-cyclodextrin in models of α-synucleinopathy. J. Neurochem. 98, 1032–1045.
4. Beavan, M.S., and Schapira, A.H. (2013). Glucocerebrosidase mutations and the pathogenesis of Parkinson disease. Ann. Med. 45, 511–521.
5. Beck, M. (2018). Treatment strategies for lysosomal storage disorders. Dev. Med. Child Neurol. 60, 13–18.
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