Potential role of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome-Reference-Cited by-同舟云学术

Potential role of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome

Published:2022-08-29 Issue:1 Volume:44 Page:105-112
ISSN:1868-1891
Container-title:Hormone Molecular Biology and Clinical Investigation
language:en
Short-container-title:

Author:

Alexandre-Santos Beatriz¹²^ORCID,Martins Felipe Figuerôa Tassinari Rocha¹,da Silva Gonçalves Larissa¹,de Oliveira Guimarães Clara¹,Carla-Ruggiero Fernanda¹,Magliano D’Angelo Carlo¹²^ORCID

Affiliation:

1. Histology and Embryology League , Biomedical Institute, Fluminense Federal University , Niteroi , RJ , Brazil

2. Research Center on Morphology and Metabolism, Department of Morphology , Biomedical Institute, Fluminense Federal University , Niteroi , RJ , Brazil

Abstract

Abstract Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects million women worldwide, presenting a complex pathophysiology that has not been fully elucidated yet. Recently, it has been suggested that PCOS triggers the endoplasmic reticulum (ER) stress, thus being associated with unfolded protein response (UPR) activation. Indeed, the UPR response has been associated with several pathological conditions, including in the reproductive system. Several studies demonstrated that ovarian UPR markers are upregulated in PCOS, being associated with worst ovarian outcomes, and this was ameliorated by ER stress inhibition. In this review, we aim to summarize the main findings from previous studies covering this topic, in an attempt to clarify the potential role of ER stress and the UPR response in the pathophysiology of PCOS.

Funder

CNPq

FAPERJ

CAPES

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism

Link

https://www.degruyter.com/document/doi/10.1515/hmbci-2022-0051/pdf

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