Androgen-driven COVID-19 infection – is testosterone an enemy or a friend?
Author:
Affiliation:
1. Department of Physiology, Immunology and Pathophysiology , University of Rijeka Faculty of Medicine , Rijeka , Croatia
2. Department of Clinical Microbiology , Clinical Hospital Center Rijeka , Rijeka , Croatia
Publisher
Walter de Gruyter GmbH
Subject
Endocrinology,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism
Reference15 articles.
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2. Abassi, ZA, Skorecki, K, Heyman, SM, Kinaneh, S, Armaly, Z. Covid-19 infection and mortality – a physiologist’s perspective enlightening clinical features and plausible interventional strategies. Am J Physiol Lung Cell Mol Physiol March 24, 2020;318:L1020–L1022. https://doi.org/10.1152/ajplung.00097.2020.
3. Donaldson, SH, Hirsh, A, Li, DC, Holloway, G, Chao, J, Boucher, RC, et al. Regulation of the epithelial sodium channel by serine proteases in human airways. J Biol Chem 2002;277:8338–45. https://doi.org/10.1074/jbc.M105044200.
4. Lukassen, S, Chua, RL, Trefzer, T, Kahn, NC, Schneider, MA, Muley, T, et al. SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. EMBO J 2020;39:e105114. https://doi.org/10.15252/embj.20105114.
5. Shen, LW, Mao, HJ, Wu, YL, Tanaka, Y, Zhang, W. TMPRSS2: a potential target for treatment of influenza virus and coronavirus infections. Biochimie 2017;142:1–10. https://doi.org/10.1016/j.biochi.2017.07.016.
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1. Androgens in SARS-CoV-2 Coronavirus Infections;Physiological Research;2021-12-14
2. Testosterone's Role in COVID-19;The Journal of Sexual Medicine;2021-03
3. Age-Related Changes and Sex-Related Differences in Brain Iron Metabolism;Nutrients;2020-08-27
4. Testosterone in COVID-19 – Foe, Friend or Fatal Victim?;European Endocrinology;2020
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