Hyperthermic intraperitoneal chemotherapy in ovarian cancer: an update

Author:

Revaux Aurélie12,Carbonnel Marie23,Kanso Frédéric4,Naoura Iptissem23,Asmar Jennifer23,Kadhel Philippe235,Ayoubi Jean-Marc23

Affiliation:

1. Department of Gynecology and Obstetrics , Foch Hospital , 40 Rue Worth , 92150 Suresnes , France

2. Faculté de Médecine Paris Ouest (UVSQ) , Versailles , France

3. Department of Gynecology and Obstetrics , Foch Hospital , Suresnes , France

4. Department of Digestive Surgery , Foch Hospital , Suresnes , France

5. CHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) – UMR_S 1085 , Pointe-à-Pitre , France

Abstract

Abstract In the treatment of advanced-stage epithelial ovarian cancer (EOC)-associated surgery and chemotherapy with intravenous platinum/taxane-based therapy most patients had early or late recurrence. Prevention of progression and recurrence is a major objective for the management of EOC. Recently, many clinical studies have evaluated the strategy with hyperthermic intraoperative intraperitoneal (IP) drug delivery. This is an update of hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in EOC and a view for future strategies. Until recently studies on HIPEC in patients with EOC were mostly retrospective and heterogeneous. Thanks to recent clinical trials, it is reasonable to conclude that surgical cytoreduction and HIPEC is an interesting approach in the management of EOC without increasing morbidity.

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism

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