Mature cystic ovarian teratoma with squamous cell carcinoma transformation: a case report and literature review-Reference-Cited by-同舟云学术

Mature cystic ovarian teratoma with squamous cell carcinoma transformation: a case report and literature review

Published:2024-01-30 Issue:0 Volume:0 Page:
ISSN:1868-1883
Container-title:Hormone Molecular Biology and Clinical Investigation
language:en
Short-container-title:

Author:

Abdoli Shadbad Mahdi¹^ORCID,Derogar Roghaiyeh²,Shekarchi Ali Akbar³,Akbari Farideh²,Jafari Shobeiri Mehri²

Affiliation:

1. Student Research Committee , Tabriz University of Medical Sciences , Tabriz , Iran

2. Fellowship in Gynecologic Oncology, Women’s Reproductive Health Research Center , Tabriz University of Medical Sciences , Tabriz , Iran

3. Department of Pathology , Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz , Iran

Abstract

Abstract Objectives Cancerous transformation in mature cystic ovarian teratoma is rare. Herein, we reported a case of squamous cell carcinoma transformation in mature cystic ovarian teratoma and performed an in-depth literature review to highlight the risk factors, prognosis, and suggested treatment for these patients. Case presentation We report a 66-years old postmenopausal woman diagnosed with a 120×90 (mm) mass at the left adnexa compatible with mature cystic ovarian teratoma. Following resection, the histopathological investigations showed malignant transformation in her mature cystic ovarian teratoma, and the immunohistochemistry for cytokeratin (CK) 5/6 and tumor protein 63 (P63) indicated squamous cell carcinoma transformation. She has been observed for her stage IA tumor and has been cancer-free for 6 months. Conclusions Although malignant transformation in mature cystic ovarian teratoma is rare, it should be suspected if certain risk factors, e.g., elderly and high tumor size, exist. Stage IA patients’ prognosis is favorable, and chemotherapy is not recommended.

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism

Link

https://www.degruyter.com/document/doi/10.1515/hmbci-2023-0001/pdf

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