Is there any role of interleukin-6 and high sensitive C-reactive protein in predicting IVF/ICSI success? A prospective cohort study
Author:
Ozgu-Erdinc A. Seval1ORCID, Gozukara Ilay1, Kahyaoglu Serkan1, Yilmaz Saynur1, Yumusak Omer Hamit1, Yilmaz Nafiye1, Erkaya Salim1, Engin-Ustun Yaprak1
Affiliation:
1. University of Health Sciences, Ankara City Hospital , Ankara , Turkey
Abstract
Abstract
Objectives
Studies have established a relationship between proinflammatory factors and implantation failure in IVF/ICSI cycles. Likewise, low-grade chronic inflammation is generally blamed for predisposing infertility. In the present study, we aimed to find a relationship between serum IL-6 and hs-CRP levels and IVF/ICSI cycle outcomes.
Methods
A total of 129 patients who consented to participate and attended the IVF unit of our department for the treatment of infertility have been enrolled in this prospective cohort study. Serum levels of high sensitive C-reactive protein and interleukin 6 have been detected at the beginning of the IVF/ICSI ovulation induction cycle. Cycle outcomes have been compared between patients with and without clinical pregnancy achievement following ART treatments. IVF/ICSI cycle outcomes of these two groups were also comparable except the number of >14 mm follicles, retrieved oocytes, metaphase II oocytes, and fertilized oocytes (2 pronuclei) which were in favor of the clinical pregnancy group.
Results
Mean serum hs-CRP levels were 3.08 mg/L (0.12–35.04) and 2.28 mg/L (0.09–22.52) patients with and without clinical pregnancy respectively. Mean serum IL-6 levels were 2 pg/mL (1–10.2) and 2 pg/mL (1–76.9) patients with and without clinical pregnancy respectively. Both tests were found to be statistically insignificant in predicting the success of the ART cycle in terms of implantation, clinical pregnancy, miscarriage, and live birth.
Conclusions
In the present study, we have not found any significant effect of hs-CRP and IL-6 levels in the IVF cycle. However, in the light of this and previous studies, large-scale research may prove the exact influence of these markers on IVF success.
Publisher
Walter de Gruyter GmbH
Subject
Endocrinology,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism
Reference46 articles.
1. Daney de Marcillac, F, Pinton, A, Guillaume, A, Sagot, P, Pirrello, O, Rongieres, C. What are the likely IVF/ICSI outcomes if there is a discrepancy between serum AMH and FSH levels? A multicenter retrospective study. J Gynecol Obstet Hum Reprod 2017;46:629–35. https://doi.org/10.1016/j.jogoh.2017.08.001. 2. Kahyaoglu, I, Dogru, HY, Aksakal, SE, Kaplanoglu, I, Dilbaz, S, Mollamahmutoglu, L. The effect of elevated basal follicle stimulating hormone levels on assisted reproductive technology cycle outcomes. Gynecol Obstet Reprod Med 2021;27:138–42. https://doi.org/10.21613/gorm.2019.998. 3. Necula, D, Gmuer, A, Mathis, J. The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation. Horm Mol Biol Clin Investig 2021. https://doi.org/10.1515/hmbci-2020-0082. 4. Norwitz, ER, Schust, DJ, Fisher, SJ. Implantation and the survival of early pregnancy. N Engl J Med 2001;345:1400–8. https://doi.org/10.1056/nejmra000763. 5. Rubod, C, Fouquet, A, Bartolo, S, Lepage, J, Capelle, A, Lefebvre, C, et al.. Factors associated with pregnancy after in vitro fertilization in infertile patients with posterior deep pelvic endometriosis: a retrospective study. J Gynecol Obstet Hum Reprod 2019;48:235–9. https://doi.org/10.1016/j.jogoh.2018.06.002.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|