Affiliation:
1. Department of Biochemistry , Faculty of Medicine & Health Sciences, SGT University , Gurugram , Haryana , India
Abstract
Abstract
Objectives
The objective of this study is to estimate lipid parameters in subclinical hypothyroidism and correlate it with TSH.
Methods
Forty newly diagnosed cases of subclinical hypothyroidism and Forty age and gender-matched healthy controls were recruited for the study. Blood samples were collected from them and serum lipid profile (i.e. HDL, LDL, TG, serum total cholesterol) of the subjects was estimated by standard photometric methods in a fully auto-analyzer (MINDRAY BS-300) using commercially available kits and VLDL cholesterol was calculated using the Friedewald’s formula. While serum Ox-LDL, Lipoprotein A, Apolipoprotein A1 and Apo B were estimated by using commercial kit based on enzyme-linked immmunosorbent assay.
Results
The parameters such as Oxidized low-density lipoprotein (Ox-LDL), lipoprotein (a), apolipoprotein A1, apolipoprotein B and small dense lipoprotein (sd LDL) were significantly increased in subclinical hypothyroid cases when compared with the control subjects (p<0.0001). In present study results showed significant positive correlations of serum thyroid stimulating hormone (TSH) with Ox-LDL (r=0.85, p<0.01), sd LDL (r=0.71, p<0.01).
Conclusions
The present study focuses on the role of Ox-LDL, sd-LDL Lipoprotein A, Apolipoprotein A1 and Apo B that are sensitive indicators of atherogenic dyslipidemia in subclinical hypothyroidism and can serve as a better & novel risk factor for CAD.
Subject
Endocrinology,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism
Reference31 articles.
1. Devdhar, M, Ousman, YH, Burman, KD. Hypothyroidism. Endocrinol Metab Clin N Am 2007;36:595–615. https://doi.org/10.1016/j.ecl.2007.04.008.
2. Gaitonde, DY, Rowley, KD, Sweeney, LB. Hypothyroidism: an update. S Afr Fam Pract 2012;54:384–90. https://doi.org/10.1080/20786204.2012.10874256.
3. Singer, PA. Thyroiditis. Acute, subacute, and chronic. Med Clin 1991;75:61–77. https://doi.org/10.1016/s0025-7125(16)30472-2.
4. Dominguez, LJ, Bevilacqua, M, DiBella, G, Barbagallo, M. Diagnosing and managing thyroid disease in the nursing home. J Am Med Dir Assoc 2008;9:9–17. https://doi.org/10.1016/j.jamda.2007.07.011.
5. Wiersinga, WM. Thyroid disease manager. Adult hypothyroidism. 2014. Available from: http://www.thyroidmanager.org/chapter/adult-hypothyroidism [Accessed 12 Jan 2012].
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